GSE20677

Platform: HG-U133_Plus_2

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Gene Expression in Gold Nanoparticle Oligonucleotide Complexes treated Primary Immune Cells

Citation:

Kim EY, Schulz R, Swantek P, Kunstman K et al. Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes. Gene Ther 2012 Mar;19(3):347-53.

Set summary:

A transcriptome-wide functional analysis of gene expression implicated multiple signaling pathways specific for Au-NP oligonucleotide complexes. Exposure to Au-NP oligonucleotide complexes is also accompanied by marked activation of immune cells.


Sample_name Description Type Treatment Dose NP_size
GSM518597 PBMCs_Control_1 PBMC - -
GSM518598 PBMCs_AuNP_24hr_1 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518599 PBMCs_AuNP_48hr_1 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518600 PBMCs_Control_2 PBMC - - -
GSM518601 PBMCs_AuNP_24hr_2 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518602 PBMCs_AuNP_48hr_2 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518603 PBMCs_Oligo PBMC Oligofectamine without oligonucleotide - -
GSM518604 PBMCs_Oligo_GFP PBMC Oligofectamine with EGFP oligonucleotide - -
GSM518605 PBMCs_HIV PBMC HIV infected - -
GSM518606 293T_Control 293T - - -
GSM518607 293T_AuNP_6hr 293T AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518608 293T_AuNP_24hr 293T AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM518609 293T_AuNP_48hr 293T AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM535541 PBMC_Control_3 PBMC - - -
GSM535542 PBMC_AuNP_24hr_3 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm
GSM535543 PBMC_AuNP_48hr_3 PBMC AuNP EGFP oligonucleotide complex 10nM 13±1nm

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