E-GEOD-7010

Platform: HG-U133A

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Transcription profiling of human primary epithelial cells exposed to coarse, fine and ultrafine particles

Citation:

Huang YC, Karoly ED, Dailey LA, Schmitt MT, Silbajoris R, Graff DW, Devlin RB. J Toxicol Environ Health A. 2011;74(5):296-312. Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter.

Set summary:

The purpose of this study was to characterize global gene expression in human airway epithelial cells and identify cellular pathways associated with coarse, fine and ultrafine particulate matter (PM) exposures. Ambient PM was collected in 3 different size fractions from Chapel Hill air, particles were extracted from foam or filter matrices and lyophilized. Human primary airway epithelial cells were exposed to particles at 250μg/ml or vehicle control for 6h in culture. Following exposure, RNA was isolated and hybridized to human HG U133A affymetrix chips.


Sample_name Description Type Treatment Dose NP_size
GSM161787 89 control exp1 primary airway epithelial cells vehicle - -
GSM161788 90 coarse exp1 primary airway epithelial cells coarse PM (Chapel Hill) 250 μg/ml 2.5-10µm
GSM161790 91 fine exp 1 primary airway epithelial cells fine PM (Chapel Hill) 250 μg/ml 0.1-2.5µm
GSM161791 92 UTF exp1 primary airway epithelial cells ultrafine PM (Chapel Hill) 250 μg/ml <0.1µm
GSM161793 93 control exp2 primary airway epithelial cells vehicle - -
GSM161794 94 coarse exp2 primary airway epithelial cells coarse PM (Chapel Hill) 250 μg/ml 2.5-10µm
GSM161796 95 fine exp2 primary airway epithelial cells fine PM (Chapel Hill) 250 μg/ml 0.1-2.5µm
GSM161797 96 UTF exp2 primary airway epithelial cells ultrafine PM (Chapel Hill) 250 μg/ml <0.1µm
GSM161798 97 control exp3 primary airway epithelial cells vehicle - -
GSM161800 98 coarse exp3 primary airway epithelial cells coarse PM (Chapel Hill) 250 μg/ml 2.5-10µm
GSM161801 99 fine exp3 primary airway epithelial cells fine PM (Chapel Hill) 250 μg/ml 0.1-2.5µm
GSM161802 100 UTF exp3 primary airway epithelial cells ultrafine PM (Chapel Hill) 250 μg/ml <0.1µm

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