E-TABM-679

Platform: Illumina HumanHT-12 V3.0 expression beadchip

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Transcription profiling of human lung epithelial cells (A549) treated with nano- and micro-sized silica and carbon particles to study toxic effects related to size and chemical origin

Citation:

Set summary:

To screen for novel toxicological endpoints of nano-particles, we conducted an in vitro expression profiling study using human lung epithelial cells (A549). To identify effects that are specific to size or chemical origin, we compared gene expression of A549 cells treated with nano-sized and micro-sized particulates of two chemical origins (carbon and silica) to the control (untreated) cells.


Sample_name Description Type Treatment Dose NP_size
A549 culture 1 control_1 A549 none - -
A549 culture 2 control_2 A549 none - -
A549 culture 3 control_3 A549 none - -
A549 culture 4 control_4 A549 none - -
A549 culture 5 control_5 A549 none - -
A549 culture 6 control_6 A549 none - -
A549 culture 7 silica quartz_1 A549 silica quartz 133µg/cm2 NA
A549 culture 8 silica quartz_2 A549 silica quartz 133µg/cm2 NA
A549 culture 9 silica quartz_3 A549 silica quartz 133µg/cm2 NA
A549 culture 10 silica quartz_4 A549 silica quartz 133µg/cm2 NA
A549 culture 11 silica quartz_5 A549 silica quartz 133µg/cm2 NA
A549 culture 12 silica quartz_6 A549 silica quartz 133µg/cm2 NA
A549 culture 13 silica micro_1 A549 silica micro 133µg/cm2 NA
A549 culture 14 silica micro_2 A549 silica micro 133µg/cm2 NA
A549 culture 15 silica micro_3 A549 silica micro 133µg/cm2 NA
A549 culture 16 silica micro_4 A549 silica micro 133µg/cm2 NA
A549 culture 17 silica micro_5 A549 silica micro 133µg/cm2 NA
A549 culture 18 silica micro_6 A549 silica micro 133µg/cm2 NA
A549 culture 19 silica nano_1 A549 silica nano 66.5µg/cm2 NA
A549 culture 20 silica nano_2 A549 silica nano 66.5µg/cm2 NA
A549 culture 21 silica nano_3 A549 silica nano 66.5µg/cm2 NA
A549 culture 22 silica nano_4 A549 silica nano 66.5µg/cm2 NA
A549 culture 23 silica nano_5 A549 silica nano 66.5µg/cm2 NA
A549 culture 24 silica nano_6 A549 silica nano 66.5µg/cm2 NA
A549 culture 25 carbon black_1 A549 carbon black 66.5µg/cm2 NA
A549 culture 26 carbon black_2 A549 carbon black 66.5µg/cm2 NA
A549 culture 27 carbon black_3 A549 carbon black 66.5µg/cm2 NA
A549 culture 28 carbon black_4 A549 carbon black 66.5µg/cm2 NA
A549 culture 29 carbon black_5 A549 carbon black 66.5µg/cm2 NA
A549 culture 30 carbon black_6 A549 carbon black 66.5µg/cm2 NA
A549 culture 31 multiwall carbon nano tubes_1 A549 multiwall carbon nano tubes 133µg/cm2 NA
A549 culture 32 multiwall carbon nano tubes_2 A549 multiwall carbon nano tubes 133µg/cm2 NA
A549 culture 33 multiwall carbon nano tubes_3 A549 multiwall carbon nano tubes 133µg/cm2 NA
A549 culture 34 multiwall carbon nano tubes_4 A549 multiwall carbon nano tubes 133µg/cm2 NA
A549 culture 35 multiwall carbon nano tubes_5 A549 multiwall carbon nano tubes 133µg/cm2 NA
A549 culture 36 multiwall carbon nano tubes_6 A549 multiwall carbon nano tubes 133µg/cm2 NA

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