GSE14910

Platform: Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Transcriptional responses to nanoparticulate matter in human colon cancer cells.

Citation:

Moos PJ, Olszewski K, Honeggar M, Cassidy P et al. Responses of human cells to ZnO nanoparticles: a gene transcription study. Metallomics. 2011 Nov;3(11):1199-211.

Set summary:

This study evaluated transcriptional effects of particles smaller than 100 nm of carbon black, SiO2, Al2O3, TiO2, ZnO and Fe203. Since there is concern that inflammation may increase the uptake and/or toxicity of ultrafine particles, we evaluated the transcriptional responses without or with a TNFα pretreatment to mimic an inflammatory state.The most pronounced transcriptional response resulted from ZnO treatement, another response was to TNFα pre-treatment. We identified stress responses, responses to Zn ions, but did not observe a consistent proinflammatory response as evaluated by Gene Ontology of the genes that altered expression most as identified by significance analysis.


Sample_name Description Type Treatment Dose NP_size
GSM372485 RKO_TNFα pretreatment RKO TNFα pretreatment; media - -
GSM372486 RKO_TNFα pretreatment replicate RKO TNFα pretreatment; media - -
GSM372487 RKO_TNFα pretreatment_nanoZnO RKO TNFα pretreatment; 5 μg/cm2 nanoZnO 5 μg/cm2 8-10nm
GSM372488 RKO_BSA pretreatment_nanoZnO RKO BSA pretreatment; 5 μg/cm2 nanoZnO 5 μg/cm2 8-10nm
GSM372489 RKO_TNFα pretreatment_nanoFe2O3 RKO TNFα pretreatment; 10 μg/cm2 nanoFe2O3 10 μg/cm2 3nm
GSM372490 RKO_BSA pretreatment_nanoFe2O3 RKO BSA pretreatment; 10 μg/cm2 nanoFe2O3 10 μg/cm2 3nm
GSM372491 RKO_TNFα pretreatment_nanoSiO2 RKO TNFα pretreatment; 50 μg/cm2 nanoSiO2 50 μg/cm2 10nm
GSM372492 RKO_BSA pretreatment_nanoSiO2 RKO BSA pretreatment; 50 μg/cm2 nanoSiO2 50 μg/cm2 10nm
GSM372493 RKO_TNFα pretreatment_nanoTiO2 RKO TNFα pretreatment; 50 μg/cm2 nanoTiO2 50 μg/cm2 5nm
GSM372494 RKO_BSA pretreatment_nanoTiO2 RKO BSA pretreatment; 50 μg/cm2 nanoTiO2 50 μg/cm2 5nm
GSM372495 RKO_TNFα pretreatment_nanoAl2O3 RKO TNFα pretreatment; 50 μg/cm2 nanoAl2O3 50 μg/cm2 NA
GSM372496 RKO_BSA pretreatment_nanoAl2O3 RKO BSA pretreatment; 50 μg/cm2 nanoAl2O3 50 μg/cm2 NA
GSM372497 RKO_TNFα pretreatment_nano-carbon black RKO TNFα pretreatment; 50 μg/cm2 nano-carbon black 50 μg/cm2 NA
GSM372498 RKO_BSA pretreatment_nano-carbon black RKO BSA pretreatment; 50 μg/cm2 nano-carbon black 50 μg/cm2 NA
GSM372499 CaCo2_TNFα pretreatment CaCo2 TNFα pretreatment; media - -
GSM372500 CaCo2_TNFα pretreatment replicate CaCo2 TNFα pretreatment; media - -
GSM372501 CaCo2_TNFα pretreatment_nanoZnO CaCo2 TNFα pretreatment; 5 μg/cm2 nanoZnO 5 μg/cm2 8-10nm
GSM372502 CaCo2_BSA pretreatment_nanoZnO CaCo2 BSA pretreatment; 5 μg/cm2 nanoZnO 5 μg/cm2 8-10nm
GSM372503 CaCo2_TNFα pretreatment_nanoFe2O3 CaCo2 TNFα pretreatment; 10 μg/cm2 nanoFe2O3 10 μg/cm2 3nm
GSM372504 CaCo2_BSA pretreatment_nanoFe2O3 CaCo2 BSA pretreatment; 10 μg/cm2 nanoFe2O3 10 μg/cm2 3nm
GSM372505 CaCo2_TNFα pretreatment_nanoSiO2 CaCo2 TNFα pretreatment; 50 μg/cm2 nanoSiO2 50 μg/cm2 10nm
GSM372506 CaCo2_BSA pretreatment_nanoSiO2 CaCo2 BSA pretreatment; 50 μg/cm2 nanoSiO2 50 μg/cm2 10nm
GSM372507 CaCo2_TNFα pretreatment_nanoTiO2 CaCo2 TNFα pretreatment; 50 μg/cm2 nanoTiO2 50 μg/cm2 5nm
GSM372508 CaCo2_BSA pretreatment_nanoTiO2 CaCo2 BSA pretreatment; 50 μg/cm2 nanoTiO2 50 μg/cm2 5nm
GSM372509 CaCo2_TNFα pretreatment_nanoAl2O3 CaCo2 TNFα pretreatment; 50 μg/cm2 nanoAl2O3 50 μg/cm2 NA
GSM372510 CaCo2_BSA pretreatment_nanoAl2O3 CaCo2 BSA pretreatment; 50 μg/cm2 nanoAl2O3 50 μg/cm2 NA
GSM372511 CaCo2_TNFα pretreatment_nano-carbon black CaCo2 TNFα pretreatment; 50 μg/cm2 nano-carbon black 50 μg/cm2 NA
GSM372512 CaCo2_BSA pretreatment_nano-carbon black CaCo2 BSA pretreatment; 50 μg/cm2 nano-carbon black 50 μg/cm2 NA
GSM372513 RKO_TNFα pretreatment_microZnO RKO TNFα pretreatment; 5 μg/cm2 microZnO 5 μg/cm2 >44µm
GSM372514 RKO_BSA pretreatment_microZnO RKO BSA pretreatment; 5 μg/cm2 microZnO 5 μg/cm2 >44µm
GSM372515 CaCo2_TNFα pretreatment_microZnO CaCo2 TNFα pretreatment; 5 μg/cm2 microZnO 5 μg/cm2 >44µm
GSM372516 CaCo2_BSA pretreatment_microZnO CaCo2 BSA pretreatment; 5 μg/cm2 microZnO 5 μg/cm2 >44µm

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