GSE42066

Platform: Affymetrix GeneChip Human Genome U133 Plus 2.0

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression [Caco-2/HT29-MTX cells]

Citation:

Tilton SC, Karin NJ, Tolic A, Xie Y et al. Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns. Nanotoxicology 2014 Aug;8(5):533-48.

Set summary:

To identify key biological pathways that define toxicity or biocompatibility after nanoparticle exposure, three human cell types were exposed in vitro to two high aspect ratio nanoparticles for 1 hr or 24 hr and collected for global transcriptomics. Transcriptional responses were measured by global microarray analysis of cells in culture.


Sample_name Description Type Treatment Dose NP_size
GSM1031875 Caco2_CON_0_1hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031876 Caco2_CON_0_1hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031877 Caco2_CON_0_1hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031878 Caco2_MWCNT_10_1hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031879 Caco2_MWCNT_10_1hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031880 Caco2_MWCNT_10_1hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031881 Caco2_MWCNT_100_1hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031882 Caco2_MWCNT_100_1hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031883 Caco2_MWCNT_100_1hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031884 Caco2_TiO2_10_1hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031885 Caco2_TiO2_10_1hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031886 Caco2_TiO2_10_1hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031887 Caco2_TiO2_100_1hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031888 Caco2_TiO2_100_1hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031889 Caco2_TiO2_100_1hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031890 Caco2_CON_0_24hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031891 Caco2_CON_0_24hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031892 Caco2_CON_0_24hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) control - -
GSM1031893 Caco2_MWCNT_10_24hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031894 Caco2_MWCNT_10_24hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031895 Caco2_MWCNT_10_24hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031896 Caco2_MWCNT_100_24hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031897 Caco2_MWCNT_100_24hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031898 Caco2_MWCNT_100_24hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031899 Caco2_TiO2_10_24hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031900 Caco2_TiO2_10_24hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031901 Caco2_TiO2_10_24hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031902 Caco2_TiO2_100_24hr-1 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031903 Caco2_TiO2_100_24hr-2 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031904 Caco2_TiO2_100_24hr-3 human colorectal/colon adenocarcinoma (Caco-2/HT29-MTX) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm

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