GSE42068

Platform: Affymetrix GeneChip Human Genome U133 Plus 2.0

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression [THP-1 cells]

Citation:

Tilton SC, Karin NJ, Tolic A, Xie Y et al. Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns. Nanotoxicology 2014 Aug;8(5):533-48.

Set summary:

To identify key biological pathways that define toxicity or biocompatibility after nanoparticle exposure, three human cell types were exposed in vitro to two high aspect ratio nanoparticles for 1 hr or 24 hr and collected for global transcriptomics.Transcriptional responses were measured by global microarray analysis of cells in culture.


Sample_name Description Type Treatment Dose NP_size
GSM1031935 THP1_CON_0_1hr-1 human acute monocytic leukemia (THP-1) control - -
GSM1031936 THP1_CON_0_1hr-2 human acute monocytic leukemia (THP-1) control - -
GSM1031937 THP1_CON_0_1hr-3 human acute monocytic leukemia (THP-1) control - -
GSM1031938 THP1_MWCNT_10_1hr-1 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031939 THP1_MWCNT_10_1hr-2 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031940 THP1_MWCNT_10_1hr-3 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031941 THP1_MWCNT_100_1hr-1 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031942 THP1_MWCNT_100_1hr-2 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031943 THP1_MWCNT_100_1hr-3 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031944 THP1_TiO2_10_1hr-1 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031945 THP1_TiO2_10_1hr-2 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031946 THP1_TiO2_10_1hr-3 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031947 THP1_TiO2_100_1hr-1 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031948 THP1_TiO2_100_1hr-2 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031949 THP1_TiO2_100_1hr-3 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031950 THP1_CON_0_24hr-1 human acute monocytic leukemia (THP-1) control - -
GSM1031951 THP1_CON_0_24hr-2 human acute monocytic leukemia (THP-1) control - -
GSM1031952 THP1_CON_0_24hr-3 human acute monocytic leukemia (THP-1) control - -
GSM1031953 THP1_MWCNT_10_24hr-1 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031954 THP1_MWCNT_10_24hr-2 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031955 THP1_MWCNT_10_24hr-3 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 10μg/ml length 5-10μm, diameter 20-30nm.
GSM1031956 THP1_MWCNT_100_24hr-1 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031957 THP1_MWCNT_100_24hr-2 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031958 THP1_MWCNT_100_24hr-3 human acute monocytic leukemia (THP-1) multi-walled carbon nanotubes (MWCNT) 100μg/ml length 5-10μm, diameter 20-30nm.
GSM1031959 THP1_TiO2_10_24hr-1 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031960 THP1_TiO2_10_24hr-2 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031961 THP1_TiO2_10_24hr-3 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 10μg/ml 7μm, 0.2μm, 0.01μm
GSM1031962 THP1_TiO2_100_24hr-1 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031963 THP1_TiO2_100_24hr-2 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm
GSM1031964 THP1_TiO2_100_24hr-3 human acute monocytic leukemia (THP-1) titanium nanobelts (TiO2-NB) 100μg/ml 7μm, 0.2μm, 0.01μm

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