GSE45322

Platform: Affymetrix Human Gene 1.0 ST Array

Organism: Homo sapiens

Pdf version of the dendrogram

Set title:

Expression data from human olfactory neurosphere derived cells (hONS) established from adult donors treated with coated and uncoated ZnO nanoparticles

Citation:

Set summary:

ZnO nanoparticles can elicit a range of cytotoxic responses in different cells in vitro that may reflect either Zn2+ dissolution or nanoparticle-specific effects. Coating the ZnO nanoparticles may mitigate their cytotoxicity. We aimed to capture whole genome transcriptional profiles (up and down regulated) at time-points associated with distinct cytotoxic responses in cells treated with two types of uncoated (Nanosun, Z-COTE) or two types of coated (HP1, MAX) ZnO nanoparticles, compared to untreated cells.


Sample_name Description Type Treatment Dose NP_size
GSM1101918 hONS cells_unntreated_ 2h, biological rep 1 hONS none -
GSM1101919 hONS cells_unntreated_ 2h, biological rep 2 hONS none -
GSM1101920 hONS cells_unntreated_ 2h, biological rep 3 hONS none -
GSM1101921 hONS cells_unntreated_ 2h, biological rep 4 hONS none -
GSM1101922 hONS cells_Nanosun-treated_ 2h, biological rep 1 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101923 hONS cells_Nanosun-treated_ 2h, biological rep 2 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101924 hONS cells_Nanosun-treated_ 2h, biological rep 3 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101925 hONS cells_Nanosun-treated_ 2h, biological rep 4 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101926 hONS cells_Z-COTE-treated_ 2h, biological rep 1 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101927 hONS cells_Z-COTE-treated_ 2h, biological rep 2 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101928 hONS cells_Z-COTE-treated_ 2h, biological rep 3 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101929 hONS cells_Z-COTE-treated_ 2h, biological rep 4 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101930 hONS cells_HP1-treated_ 2h, biological rep 1 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101931 hONS cells_HP1-treated_ 2h, biological rep 2 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101932 hONS cells_HP1-treated_ 2h, biological rep 3 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101933 hONS cells_HP1-treated_ 2h, biological rep 4 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101934 hONS cells_MAX-treated_ 2h, biological rep 1 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101935 hONS cells_MAX-treated_ 2h, biological rep 2 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101936 hONS cells_MAX-treated_ 2h, biological rep 3 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101937 hONS cells_MAX-treated_ 2h, biological rep 4 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101938 hONS cells_unntreated_ 6h, biological rep 1 hONS none -
GSM1101939 hONS cells_unntreated_ 6h, biological rep 2 hONS none -
GSM1101940 hONS cells_unntreated_ 6h, biological rep 3 hONS none -
GSM1101941 hONS cells_unntreated_ 6h, biological rep 4 hONS none -
GSM1101942 hONS cells_Nanosun-treated_ 6h, biological rep 1 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101943 hONS cells_Nanosun-treated_ 6h, biological rep 2 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101944 hONS cells_Nanosun-treated_ 6h, biological rep 3 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101945 hONS cells_Nanosun-treated_ 6h, biological rep 4 hONS ZnO nanoparticles (Nanosun) 25μg/ml
GSM1101946 hONS cells_Z-COTE-treated_ 6h, biological rep 1 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101947 hONS cells_Z-COTE-treated_ 6h, biological rep 2 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101948 hONS cells_Z-COTE-treated_ 6h, biological rep 3 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101949 hONS cells_Z-COTE-treated_ 6h, biological rep 4 hONS ZnO nanoparticles (Z-COTE) 25μg/ml
GSM1101950 hONS cells_HP1-treated_ 6h, biological rep 1 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101951 hONS cells_HP1-treated_ 6h, biological rep 2 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101952 hONS cells_HP1-treated_ 6h, biological rep 3 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101953 hONS cells_HP1-treated_ 6h, biological rep 4 hONS ZnO nanoparticles (HP1) 25μg/ml
GSM1101954 hONS cells_MAX-treated_ 6h, biological rep 1 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101955 hONS cells_MAX-treated_ 6h, biological rep 2 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101956 hONS cells_MAX-treated_ 6h, biological rep 3 hONS ZnO nanoparticles (MAX) 25μg/ml
GSM1101957 hONS cells_MAX-treated_ 6h, biological rep 4 hONS ZnO nanoparticles (MAX) 25μg/ml

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